Rybelsus (semaglutide) is an oral GLP-1 receptor agonist indicated for the treatment of adults with insufficiently controlled Type 2 diabetes mellitus. The 3mg strength is the initiation dose, specifically designed to allow the body to adjust to the medication during the first 30 days of treatment.
The 3mg dose is intended for treatment initiation only and is not effective for long-term glycaemic control. Following the first month, the dose is typically increased to the therapeutic 7mg or 14mg maintenance levels as directed by a healthcare professional.
To ensure effective absorption of the medication, the following instructions must be followed strictly:
Timing: Take one tablet once daily on an empty stomach, immediately upon waking.
Water: Swallow the tablet whole with a small sip of plain water (no more than 120ml).
Waiting Period: Wait at least 30 minutes after taking the tablet before eating, drinking, or taking any other oral medications.
Integrity: Do not crush, chew, or split the tablet, as this affects the absorption of the active ingredient.
Contraindications: Do not use if you or any of your family have ever had medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Pancreatitis: Patients should be aware of the symptoms of acute pancreatitis (persistent, severe abdominal pain). If suspected, discontinue use and consult a doctor immediately.
Pregnancy: Not recommended during pregnancy. Treatment should be discontinued at least 2 months before a planned pregnancy.
Not for Type 1: This medication is not suitable for patients with Type 1 diabetes or diabetic ketoacidosis.
Original Packaging: Tablets must remain in their original blister pack or bottle until the moment of consumption to protect them from moisture.
Temperature: Store at room temperature (below 25°C).
Security: Keep out of the reach and sight of children.
Active Ingredient: Semaglutide 3mg.
Key Excipient: Salcaprozate sodium (SNAC), which facilitates the absorption of semaglutide in the stomach.